Gene home. IUPHAR DATABASE | NUCLEAR HORMONE RECEPTOR LIST. SOURCE Search : (Source::GenePage for Gene PPARG) Nuclear Receptor Signaling Atlas | Receptors, Coactivators, Corepressors and Ligands. RAR-γ - Retinoic acid receptor γ. RAR-γ is a member of the nuclear receptor superfamily of transcription factors that mediates signaling by all-trans and 9-cis retinoic acid, hormones derived from vitamin A (retinol).
Along with other members of the RAR family, RAR-γ is redundantly involved in vertebrates in the pleiotropic control of embryonic patterning and organogenesis, cell proliferation, differentiation, apoptosis and homeostatic control in multiple physiological systems. RAR-γ is expressed in mulitple organs in many major physiological systems (central nervous system (CNS), endocrine, metabolic, gastrointestinal, reproductive and cardiopulmonary), with particularly high levels in the eye, pituitary gland, adrenal gland, tongue, colon, brown adipose tissue, white adipose tissue, ovary, uterus, preputial gland, prostate, vas deferens, aorta, heart, lung and skin.
View full NURSA RARγ expression dataset RARγ dysfunction has been shown to be associated with schizophrenia and other psychiatric conditions. PPAR signaling pathway - Homo sapiens (human) PPAR-α - Peroxisome proliferator activated receptor α. PPARα is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors.
Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. PPARα is expressed primarily in metabolic tissues (brown adipose tissue, liver, kidney) but elevated levels are also present in the digestive (jejunum, ileum, colon, gall bladder) and cardiopulmonary (aorta, heart) systems. View full NURSA PPARα expression dataset Targeted disruption (knockout) of the PPARα gene is associated with defects in adipose tissue, the cardiovascular system, growth and size, homeostasis and metabolism, the immune system, life span, the liver and biliary system, muscle and skin wound healing. View PPARα Diseases and Phenotypes section. PPARδ - Peroxisome proliferator activated receptor-δ/β. PPARδ is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors.
Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. PPARδ is expressed in most physiological systems including the CNS (central nervous system), endocrine, immune, reproductive, digestive, urinary and cardiopulmonary systems, with particularly high levels in the duodenum, jejunum, ileum, colon and kidney. View full NURSA PPARδ expression dataset PPARδ dysfunction is associated with colorectal cancer, atherosclerosis, hyperlipidemia, coronary heart disease, defects in body mass, type II diabetes, metabolic syndrome and obesity, as well as Alzheimer's disease.
View PPARδ Diseases and Phenotypes section. PPAR-γ - Peroxisome proliferator activated receptor γ. PPARγ is a fatty acid-activated member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. Collectively the PPAR subfamily plays important roles in lipid and glucose metabolism, and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease.
PPARγ is expressed at low levels in most physiological systems, including the central nervous system (CNS), endocrine system, gastrointestinal system, reproductive system, cardiopulmonary system and metabolic tissues, but is most highly expressed in brown and white adipose tissue. View full NURSA PPARγ expression dataset Targeted disruption (knockout) of the PPARγ gene leads to defects in embryogensis, brown and white adipose tissue, the liver and biliary system, the cardiovascular system, the digestive system, homeostasis and metabolisn, muscle, hearing, the renal and urinary system and prenatal and perinatal lethality. PXR - Pregnane X receptor. PXR (NR1I2) FXR-α - Farnesoid receptor α.
RetrieveFile.cfm (application/pdf Object) GW 4064 Supplier | [CAS 278779-30-9] | Tocris Bioscience | GW4064. Biological Activity Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Licensing Information Sold for research purposes under agreement from GlaxoSmithKline Technical Data M.Wt: Formula: C28H22Cl3NO4 Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol Purity: Storage: Desiccate at +4°C CAS No: The technical data provided above is for guidance only.For batch specific data refer to the Certificate of Analysis. Certificate of Analysis / Safety Data Sheet References Maloney et al (2000) Identification of a chemical tool for the orphan nuclear receptor FXR.
Cariou et al (2006) The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. Zhang et al (2006) Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. View Related Products by Target.