The Ayurvedic plant Bacopa Monnieri inhibits inflammatory pathways in the brain. Effect of natural and synthetic antioxidants in a mouse model of. Effect of supplement with lactic-acid producing bacteria on fatigue. Mending the Mitochondria: Lipid Replacement Therapy for Chronic Fatigue Syndrome — Dr Courtney Craig. Several studies in CFS and fibromyalgia show evidence of increased markers of free radical damage; including DNA oxidation and lipid oxidation (1).
These markers are measured through blood or as urine organic acid metabolites. Excessive nitric oxide is also observed indicating changes in cytokines as the cycle of free radical damage ensues (1). Microbial byproducts generated from dysbiosis may also damage the mitochondria. Excessive hydrogen sulfide produced from microbe overgrowth in the small intestine (SIBO) can damage mitochondrial complexes in a dose-dependent manner similar to the action of cyanide (2).
Supplementation with mitochondrial supports are widely utilized by CFS and FM patients. Vitamins Vitamin B1, B2, B3, B6, vitamin CMinerals Magnesium, calcium, zinc, copperMetabolites CreatineCofactors CoQ10, alpha-lipoic acid, NADHTransporters L-carnitine, phospholipids (glycerophosphocholine & phosphatidylserine) Antioxidants CoQ10, acetyl-glutathione, lipoic acid. Chronic Fatigue Syndrome Integrative Interventions. Magnesium Magnesium is an essential mineral involved in hundreds of enzymatic reactions in humans, and its deficiency may be linked to chronic fatigue (Wicks 1999; Rude 2009).
Magnesium deficiency is a common and often underestimated problem (Rosanoff 2012). For example, a nationwide US survey reported that adult women consumed an average of 71% of the US Recommended Daily Allowance (RDA) of 320 mg (Rude 2009). Some, but not all, studies have reported that supplemental magnesium is helpful for people with CFS or fibromyalgia. One study reported that 20 adults with CFS had significantly lower red blood cell magnesium levels compared to 20 healthy controls. The traditional test for magnesium levels (ie, serum magnesium) can be misleading.
B-Vitamins Zinc. Find The Best Bodybuilding Supplement Offers on NutraPlanet! Pure Bulk Supplements & Nutrition Powders. PureBulk.com Vitamins & Dietary Supplements. CoQ10-NADH combo cuts fatigue in CFS – Shoutout about ME. A Spanish study has found that supplementation with CoQ10 and NADH signficantly improved fatigue in a trial involving 73 chronic fatigue syndrome patients.
The team, led by Dr Jesus Castro-Marrero, also found that ATP and citrate synthase were significantly higher, while lipoperoxides were significantly lower. A larger trial would be needed to confirm the findings. Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? By Dr. Jesus Castro-Marrero et al. Abstract Chronic Fatigue Syndrome (CFS) is a chronic and extremely debilitating illness characterized by prolonged fatigue and multiple symptoms with unknown cause, diagnostic test, or universally effective treatment. Inflammation, oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been well documented in CFS. A significant improvement of fatigue showing a reduction in FIS total score (p< 0.05) was reported in treated group vs. placebo.
Further Reading. Deficiencies in CFS/ME.
Dr Lapp's Recommendations on Supplements. By Bruce Campbell Should you take supplements?
If so, which ones and what benefits are reasonable to expect? For some answers, we turned to Dr. Charles Lapp, director ereritus of the Hunter-Hopkins Center in Charlotte, North Carolina. Dr. Dr. Dr. It must be safe. He has found 11 supplements that qualify. Dr. As he has written, the most important treatment of CFS and FM is acceptance of the illness and adaptation to it by means of lifestyle change, which focuses on pacing and includes other adjustments such as stress management. Dr. 1) Multi-vitamin To optimize overall health, he recommends using a multi-vitamin that includes B complex, folate, vitamin D, calcium and magnesium. He recommends the injectible form and says that up to 80% of people with CFS/FM who use it experience a 10% to 15% energy boost. 3) Vitamin D3He has found that virtually all his patients have low levels and recommends 2,000 units per day. Review of Nutritional Supplements Used for ME/CFS and FM. Top Recommended Suplements for CFS/ME.
Nutritional supplements are an essential component of any Chronic Fatigue Syndrome treatment protocol.
Research has shown that people with Chronic Fatigue Syndrome are routinely deficient in several important nutrients. Nutritional supplements are an essential component of any Chronic Fatigue Syndrome & Myalgic Encephalomyelitis (ME/CFS) treatment protocol. Research has shown that people with ME/CFS are routinely deficient in several important nutrients. These deficiencies can decrease the degree to which the body can absorb and make use of other nutrients.
Supplement, diets and other OTC treatments I've tried for CFS/ME. Since you're here, you might be interested in my CFS/ME/fibromyalgia treatment book.
Note: because this list was growing extremely large, I have decided to separate it into two pages. Onward Through the Fog: Supplements. [The section below is Chapter 5 of my book, Chronic Fatigue Syndrome: A Treatment Guide, 2nd Edition.
A young woman from Denmark requested that I post this chapter on my blog so she could have access to a translation.]Disclaimer: I am not a medical professional. Nothing on this blog should be interpreted as medical advice.