BRCA1 - breast cancer 1, early onset. Reviewed August 2007 What is the official name of the BRCA1 gene?
The official name of this gene is “breast cancer 1, early onset.” BRCA1 is the gene's official symbol. The BRCA1 gene is also known by other names, listed below. Read more about gene names and symbols on the About page. What is the normal function of the BRCA1 gene? The BRCA1 gene belongs to a class of genes known as tumor suppressor genes. The BRCA1 gene provides instructions for making a protein that is directly involved in repairing damaged DNA. Research suggests that the BRCA1 protein also regulates the activity of other genes and plays a critical role in embryonic development. Does the BRCA1 gene share characteristics with other genes? The BRCA1 gene belongs to a family of genes called RNF (RING-type zinc fingers). A gene family is a group of genes that share important characteristics. How are changes in the BRCA1 gene related to health conditions? Targeted Therapies for Breast Cancer Tutorial. In This Section: Inhibition of HER2 The epidermal growth factor receptor family consists of four cell surface receptors: EGF receptor, also called HER1; HER2/neu; HER3; and HER4.
Binding of specific growth factors, or ligands, to three of these receptors causes them to interact, or dimerize, either with a receptor of the same type or with another family member. HER2 is called an "orphan receptor" because it does not interact directly with any ligand. Instead, it dimerizes with ligand-bound EGF receptor, HER3, or HER4. Receptor dimerization activates signaling pathways inside the cell. HER2 in Cancer Cells The HER2 gene is amplified in 20% of breast cancers. The extra HER2 protein causes increased signal pathway activation, which contributes to the uncontrolled growth and survival of these cancers.
Breast tumors that overexpress HER2 protein are more aggressive than other breast tumors. Inhibiting HER2 Researchers have developed multiple strategies for interfering with HER2 signaling. Answers. p95HER2 and Breast Cancer. Herceptin trials in early breast cancer. 3 large trials looked into using Herceptin to treat HER2 positive early breast cancer.
They aimed to try to stop the cancer from coming back. Two of the trials were American and one was a very large European and worldwide trial called HERA. The trials looked at giving Herceptin as well as chemotherapy to women after surgery to remove their breast cancer. Herceptin MOA Video. HER2: biology, detection, and clinical i... [Arch Pathol Lab Med. 2011. HER Receptor Family - HER Signaling Pathways - Genentech BioOncology - BioOncology. Share Human epidermal growth factor receptor (HER) pathways play a critical role in cancer biology and are an area of intense research at Genentech, a member of the Roche Group.
Dysregulation of HER-mediated signaling pathways results in the growth and spread of cancer cells.1 The HER family consists of 4 structurally related receptors: HER1 (EGFR), HER2, HER3, and HER4.1,2. HER2 status in breast carcinomas. One will often hear the words "HER-2 status" when a breast cancer lesion is being diagnosed and staged for treatment.
The HER-2 (Her2/neu, c-erb-2 or erb-2) is a gene which produces a protein that acts as a receptor on the surface of cells. These receptors are very sensitive to hormonal/chemical 'growth' signals in the body, and are therefore 'growth factors'. If a cancer tumor has cells which seem to have more of these HER2 proteins than normal, that means those cells are receiving more 'messages' to grow and divide than normal cells. More specifically, HER-2/ neu, also known as c- erb B-2 (HER-2), is a a proto-oncogene located on chromosome 17. This gene is amplified therefore the protein (HER-2) overexpressed, in around 20-25% of invasive breast cancers. some proteins make breast tumors more receptive to certain hormones Sometimes the phrase 'hormone receptor status' is used along with terms like 'protein status' and HER-2 status. Fluorescent in situ hybridization References Home. Her-2 neu (Cerb-B2) expression in fine needle aspiration samples of breast carcinoma: A pilot study comparing FISH, CISH and immunocytochemistry.
HER-2/neu (c-erb-B2) gene and protein in br... [Am J Clin Pathol. 1999.