Lartigue2007GenomeTransplantation. JCVI: Home. Socrates_logos. Craig Venter is on the verge of creating synthetic life. Craig Venter unveils "synthetic life" About / Bios / J. Craig Venter. Research Interests and Accomplishments J. Craig Venter, Ph.D., is regarded as one of the leading scientists of the 21st century for his numerous invaluable contributions to genomic research.
He is Founder, Chairman, and CEO of the J. Craig Venter Institute (JCVI), a not-for-profit, research organization with approximately 300 scientists and staff dedicated to human, microbial, plant, synthetic and environmental genomic research, and the exploration of social and ethical issues in genomics. Dr. Dr. In 1998, Dr. Dr. Dr. Select Publications. About / Bios / Hamilton O. Smith. About Biographies Hamilton O. Smith, M.D. Scientific Director Synthetic Biology and Bioenergy Distinguished Professor Research Interests and Accomplishments Hamilton O. Subsequently, he studied DNA methylases and nucleases in Haemophilus influenzae Rd and discovered this organism's sequence-specific DNA uptake during genetic transformation. Publications Gibson, D. Science. 2008 Jan 24; 319(5867): 1215-20.
Lartigue, C., Glass, J. Science. 2007 Aug 03; 317(5838): 632-8. Glass, J. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2): 425-30. Hutchison, C. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48): 17332-6. Smith, H. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26): 15440-5. Venter, J. Nature. 1996 May 30; 381(6581): 364-6. Fraser, C. Science. 1995 Oct 20; 270(5235): 397-403. Fleischmann, R. Science. 1995 Jul 28; 269(5223): 496-512. Fields, C., Adams, M. Nat Genet. 1994 Jul 01; 7(3): 345-6. Search for more publications by Hamilton Smith. Related Synthetic Biology and Bioenergy Group About > Hamilton O. . © J. About / Bios / Clyde Hutchison. Clyde A. Hutchison III. Hutchison Home Page -- Research -- Publications -- Hutchison Laboratory -- Academic and Research Affiliations -- Contact Clyde -- Professional CV -- Non-Scientific Interests MOLECULAR GENETICS Research Interests This laboratory has carried out investigations on biological systems ranging from bacteriophage to mice.
The unifying theme has been a continuing search for improved methods to learn about gene function from DNA sequence information. We have been involved in genomics since before the advent of modern DNA sequencing. Clyde and Marshall Edgell dissected the genome of phage phiX174 with restriction enzymes in the 1970's, and Clyde was a member of the team in Fred Sanger's lab that sequenced the phiX174 genome; the first DNA molecule completely sequenced. Bacterial Genomics. Synthetic Genomics. The L1 retroposon in mammals. Directed mutagenesis. Selected Publications. Penn | Center for Bioethics | Home. First-self-replicating-synthetic-bacterial-cell-constructed-by-j-craig-venter-institute-researchers-94485589. ROCKVILLE, Md. and SAN DIEGO, May 20 /PRNewswire-USNewswire/ -- Researchers at the J. Craig Venter Institute (JCVI), a not-for-profit genomic research organization, published results today describing the successful construction of the first self-replicating, synthetic bacterial cell.
The team synthesized the 1.08 million base pair chromosome of a modified Mycoplasma mycoides genome. The synthetic cell is called Mycoplasma mycoides JCVI-syn1.0 and is the proof of principle that genomes can be designed in the computer, chemically made in the laboratory and transplanted into a recipient cell to produce a new self-replicating cell controlled only by the synthetic genome.
This research will be published by Daniel Gibson et al in the May 20th edition of Science Express and will appear in an upcoming print issue of Science. According to Dr. The JCVI team employed a three stage process using their previously described yeast assembly system to build the genome using the 1,078 cassettes. Dr. Dr. Physiology or Medicine 1978 - Press Release.
Press Release October 1978 The Nobel Assembly of Karolinska Institutet has decided to award the Nobel Prize in Physiology or Medicine for 1978 jointly to Werner Arber, Dan Nathans and Hamilton Smith for the discovery of "restriction enzymes and their application to problems of molecular genetics". Summary Restriction enzymes provide the "chemical knives" to cut genes (= DNA) into defined fragments. Arber discovered restriction enzymes. Smith verified Arber's hypothesis with a purified bacterial restriction enzyme and showed that this enzyme cuts DNA in the middle of a specific symmetrical sequence. Nathans pioneered the application of restriction enzymes to genetics. This year's Nobel Prize in medicine or physiology is awarded for discoveries with far reaching consequences for genetics. Restriction enzymes are used as tools to dissect DNA into smaller defined fragments. Werner Arber started this field of research in Geneva during the 1960's.
Hamilton Smith verified Arber's hypothesis.