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Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum

Reconsideration of the immunotherapeutic pediatric safe dose levels of aluminum
1. Introduction Aluminum is used as an adjuvant in vaccines licensed by the US Food and Drug Administration [[1], [2], [3], [4], [5], [6], [7]] to enhance the immunogenicity of the vaccine in various forms (e.g., aluminum oxyhydroxide and aluminum hydroxyphosphate) [9,10] (Fig. 1). The Center for Biologics Evaluation and Research (CBER) sets the amount of aluminum per dose in biological products, including vaccines, to 850 μg aluminum if measured by assay. Two additional levels are specified by the regulations (1140 and 1250 μg respectively), depending on how the level is measured [8]. Fig. 1. The CDC schedule reflects the expected timing of administration of vaccines containing aluminum (shaded light yellow) as adjuvant at birth, 2, 4, 6, 12, and 18 months. Safety for aluminum from all sources is based on the No Observed Adverse Effect Level (NOAEL), Minimal Risk Level (MRL), and the Lowest Observed Affect Level (LOAEL) [[15], [16], [17], [18], [19], [20]]. 2. 2.1. 2.2. 3. 3.1. 3.2. 4.

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Human Exposure to Aluminum Linked to Familial Alzheimer’s Disease New research finds close association between high aluminum content and amyloid-beta Amsterdam, NL – A new study published in the Journal of Alzheimer's Disease (JAD) supports a growing body of research that links human exposure to aluminum with Alzheimer's disease (AD). Researchers found significant amounts of aluminum content in brain tissue from donors with familial AD. The study also found a high degree of co-location with the amyloid-beta protein, which leads to early onset of the disease. "This is the second study confirming significantly high brain accumulation in familial Alzheimer's disease, but it is the first to demonstrate an unequivocal association between the location of aluminum and amyloid-beta in the disease.

Imaging of aluminium and amyloid β in neurodegenerative disease C. ExleyHuman exposure to aluminium Environ. Sci. Process Impacts, 15 (2013), pp. 1807-1816 C. Infants are Uniquely Vulnerable to Aluminium in Vaccines Aluminium is Toxic In 1984, as an undergraduate at the University of Stirling, Scotland and while carrying out my first piece of independent research, I watched for the first time a fish, a salmon parr, die from acute aluminium toxicity. The whole process took less than forty-eight hours. Within six hours, the fish showed signs of distress and its behaviour changed markedly. Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimerâs disease, multiple sclerosis and autism 1.Exley, C. Human exposure to aluminium. Environ.

Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan Study population Although it is not a clinical trial, the Japan Environment and Children’s Study (JECS) is registered with the University Hospital Medical Information Network Clinical Trials Registry, number UMIN000030786. The JECS is a nationwide, multicentre, prospective birth cohort study conducted by the Ministry of Environment of Japan, and its protocol and major hypotheses have been published as a protocol paper [12,13,14,15]. A total of 103,099 pregnant women were recruited from the general population of Japan for the JECS at 15 research centres covering a wide geographical area of Japan, from the north of the country (Hokkaido) to the south (Okinawa), from April 2011 to March 2014. The pregnancies of the recruited women resulted in 104,065 newborns.

Epilepsy and Aluminium - The Hippocratic Post There is a long (and perhaps regrettable) history of the injection of aluminium salts into brain tissue in animal (including primates) models of human epilepsy. With this in mind, it may be surprising that our recent research ( is the first to measure and identify aluminium in human epilepsy. We present a case report of another victim of the Camelford water-poisoning incident ( where an exposed individual developed adult onset epilepsy and died following an epileptic seizure. The hippocampus was the main target for aluminium where it had accumulated to pathologically significant concentrations. Aluminium-specific fluorescence showed that aluminium was loaded into glial cells as well as being associated with deposits of neuronal/cellular debris.

Vaccinating a girl in her luteal phase akin to playing Russian roulette with her life – helenlobato.com Vaccinating a woman during the luteal phase of her menstrual cycle may result in a high risk of an unpredictably high immune response, and a possible life threatening cascade of events. According to Gardasil researcher Lloyd. W Phillips this is because During a woman’s Luteal Phase, the immune system “backs off” so it won’t kill a newly fertilized human egg. The immune system becomes so compromised that the dormant Epstein Barr Virus that causes Mononucleosis may wake up (become virulent).

Aluminium may cause MS: Patients have levels in their brains that 'cannot be ignored' Aluminium may cause multiple sclerosis (MS), new research suggests. Deceased patients have significantly high levels of the metal in their brains, a study found. Exposure to aluminium, which is added to vaccines and antiperspirants, is thought to interact with a patient's genes, causing their immune system to mistakenly attack the layer that surrounds nerves.

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