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Biofilm

Biofilm
IUPAC definition Aggregate of microorganisms in which cells that are frequently embedded within a self-produced matrix of extracellular polymeric substance (EPS) adhere to each other and/or to a surface. Note 1: A biofilm is a fixed system that can be adapted internally to environmental conditions by its inhabitants. Note 2: The self-produced matrix of extracellular polymeric substance, which is also referred to as slime, is a polymeric conglomeration generally composed of extracellularbiopolymers in various structural forms.[1] Microbes form a biofilm in response to many factors, which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics.[4][5] When a cell switches to the biofilm mode of growth, it undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated.[6] Formation[edit] Development[edit] Related:  Morgellons & LymeResearch/parasites&protocol (theories).caisson test.caisson test

Newly Discovered Rope Worm Infection Wow. This is amazing. And horrifying. Notice that he mentions the role of heavy metals toward the end. Obviously, a heavy metal cleanse such as EDTA and DMSA would be helpful in the process of cleansing and eliminating. These are the main ingredients of the most effective anti-parasite formulas. I've also bolded a few interesting things about these herbs that we might want to keep in mind. Parasite CleanseGreen hulls of black walnut: is known to have powerful effects on killing many varieties of parasites.The dried and ground green hull of the Black Walnut contains tannin, which is organic iodine, as well as juglandin.

Glutathione Thiol groups are reducing agents, existing at a concentration of approximately 5 mM in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmic proteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also called L-(–)-glutathione. Once oxidized, glutathione can be reduced back by glutathione reductase, using NADPH as an electron donor.[3] The ratio of reduced glutathione to oxidized glutathione within cells is often used as a measure of cellular toxicity.[4] Biosynthesis[edit] Glutathione is not an essential nutrient, since it can be synthesized in the body from the amino acids L-cysteine, L-glutamic acid, and glycine. Cells make glutathione in two adenosine triphosphate (ATP)-dependent steps: First, gamma-glutamylcysteine is synthesized from L-glutamate and cysteine via the enzyme gamma-glutamylcysteine synthetase (glutamate cysteine ligase, GCL). Function[edit] Cancer[edit]

Brane cosmology Brane cosmology refers to several theories in particle physics and cosmology related to string theory, superstring theory and M-theory. Brane and bulk[edit] The central idea is that the visible, four-dimensional universe is restricted to a brane inside a higher-dimensional space, called the "bulk" (also known as "hyperspace"). If the additional dimensions are compact, then the observed universe contains the extra dimensions, and then no reference to the bulk is appropriate. In the bulk model, at least some of the extra dimensions are extensive (possibly infinite), and other branes may be moving through this bulk. Why gravity is weak and the cosmological constant is small[edit] Some versions of brane cosmology, based on the large extra dimension idea, can explain the weakness of gravity relative to the other fundamental forces of nature, thus solving the so-called hierarchy problem. Models of brane cosmology[edit] The authors discussed the possibility that the Universe has See also[edit]

Cell surface receptor The seven-transmembrane α-helix structure of a G-protein-coupled receptor Structure and mechanism[edit] There are various kinds, such as glycoprotein and lipoprotein.[1] Hundreds of different receptors are known and many more are yet to be discovered.[2][3] Almost all known membrane receptors are transmembrane proteins. A certain cell membrane can have several membrane receptors with various amounts on its surface. A certain receptor may also exist at varying concentrations on different membrane surfaces, depending on the membrane and cell function. Domains[edit] Like any integral membrane protein, a transmembrane receptor may be subdivided into three parts or domains. Extracellular domain[edit] Transmembrane domain[edit] In the majority of receptors for which structural evidence exists, transmembrane alpha helices make up most of the transmembrane domain. Intracellular domain[edit] Signal transduction[edit] External reactions and internal reactions for signal transduction (click to enlarge)

Hospital Acquired Infections Costly, Preventable A program to reduce hospital-acquired infections can save an average of $1.1 million a year, according to results of a new study. In 2002, one in every 20 hospitalized patients developed a healthcare-associated infection (HAI), making HAIs one of the leading causes of death and illness in the U.S., and costing up to $33 billion dollars, according to the Department of Health and Human Services (HHS). The 1.7 million reported HAIs resulted in an estimated 99,000 deaths in that year, wrote Hugh Waters, MS, PhD, of Johns Hopkins Bloomberg School of Public Health, and colleagues in the September/October issue of the American Journal of Medical Quality. There's been "substantial uncertainty" among hospitals on how reducing infections would impact their financial performance, according to the study authors. "Without a strong business case, hospitals may be reluctant to embark on meaningful efforts to improve safety," they wrote. The Keystone program has two main components: Emily P. false

Bacteria, Biofilms, Antibiotic Resistance and Infections Bacteria are interesting and abundant microorganisms that sometimes exist as separate cells. Many bacteria grow in colonies called biofilms, however. In a biofilm, bacteria are attached to each other and to a solid surface, They are also surrounded by a protective material which they secrete. Biofilms form in our bodies. Where Are Biofilms Found? Biofilms form in many places. A biofilm often has a slimy consistency and can be large enough for us to see without magnification. How Does a Biofilm Form? The first step in biofilm production is the formation of a conditioning film on a surface. Free-floating bacteria (also called planktonic bacteria) land on the conditioning film and stick to it. The bacterial cells become surrounded by a protective material that they release, which is sticky and helps attach them to each other and to the solid surface. The extracellular matrix of a biofilm protects the bacteria from attack by the host’s immune system. Biofilms and Infections

Carnicom Institute - CDB - Growth Progressions This paper will outline specific, identifiable and repeatable growth stages of the cross-domain bacteria (CDB) and its associated forms. It will be seen that a wide variety of growth forms will ultimately emerge from what appears to be a simple, non-descript spherical living entity; as such the term 'pleomorphic' is fully justified in this presentation. This is the case even when the study is restricted to the most primitive form of existence (i.e., the CDB) and this sets the stage to for us anticipate a high level of survivability and adaptibility for the organism. The outline of presentation is based primarily upon chronology. This image above represents the basis of all subsequent work here. The above image is a clear and unhindered presentation of the CDB as they have been isolated. The photograph above is an important one and it has been difficult to capture. What are the known methods of reproduction? Two types of cells exist : prokaryotic and eukaryotic.

Beautiful Mathematical GIFs Will Mesmerize You Digital artist and physics PhD student Dave Whyte is dazzling our computer screens with his mesmerizing GIFs that are the perfect marriage of mathematics and art. And we can’t stop watching them. Whyte shares his brilliant, procrastination-fueling creations on an almost daily basis on his Tumblr account, Bees & Bombs. Whyte studies the physics of foam and told Colossal that his first geometric GIFs riffed on computational modules that he was exploring as an undergraduate student. To create his eye catching animations, Whyte uses a programming language called Processing. [Via Colossal, io9 and Bees & Bombs]

Cell migration Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations. Errors during this process have serious consequences, including intellectual disability, vascular disease, tumor formation and metastasis. An understanding of the mechanism by which cells migrate may lead to the development of novel therapeutic strategies for controlling, for example, invasive tumour cells. Cells often migrate in response to specific external signals, including chemical signals and mechanical signals. Cell migration studies[edit] The migration of cultured cells attached to a surface is commonly studied using microscopy. Common features[edit] The processes underlying mammalian cell migration are believed to be consistent with those of (non-spermatozooic) locomotion.[3] Observations in common include:

Nosocomial infection A hospital-acquired infection, also known as a HAI or in medical literature as a nosocomial infection, is an infection whose development is favored by a hospital environment, such as one acquired by a patient during a hospital visit or one developing among hospital staff. Such infections include fungal and bacterial infections and are aggravated by the reduced resistance of individual patients.[1][dead link] In the United States, the Centers for Disease Control and Prevention estimated roughly 1.7 million hospital-associated infections, from all types of microorganisms, including bacteria, combined, cause or contribute to 99,000 deaths each year.[2] In Europe, where hospital surveys have been conducted, the category of Gram-negative infections are estimated to account for two-thirds of the 25,000 deaths each year. Nosocomial infections can cause severe pneumonia and infections of the urinary tract, bloodstream and other parts of the body. Types[edit] Cause[edit] Transmission[edit]

Biofilms and Infection | ENT Kent © 2007 – 2015 JW Fairley Content last updated 18 August 2014 Disclaimer All information and advice on this website is of a general nature and may not apply to you. Complexity of biofilm. © 2003 Center for Biofilm Engineering Montana State University-Bozeman What is a biofilm? A biofilm is a community of micro-organisms, attached to a wet or moist surface. Individual micro-organisms can only be seen under a microscope. Two marvels of biological structural engineering in niche environments. Micro-organisms attach themselves to all kinds of surfaces. The plaque that builds up between the gum and the tooth is a biofilm. Biofilms also build up in humans. Biofilms start as just a few bugs forming a thin layer. Five stages of biofilm development. Graphic by Peg Dirckx and David Davies &copy 2003 Center for Biofilm Engineering Montana State University. A bug’s life Bugs, germs, bacteria, micro-organisms – we think of them as dirty and dangerous, to be avoided, controlled, exterminated. Disclaimer

Carnicom Institute - Morgellons : The Breaking of Bonds and the Reduction of Iron Three methods that appear to interfere with the molecular bonding of the iron-dipeptide complex that is now understood to be characteristic of the "Morgellons" growth structure have been established and identified. The iron-protein complex is believed to be of, or similar to, the "Rieske Protein" (iron-sulfur) form. These three methods also appear to be variably successful in reducing the oxidation state of the encapsulated iron from the Fe(III) state to the Fe(II) state. The discovered methods involve the use of ascorbic acid (Vitamin C), N-acetyl cysteine (NAC) and glutathione. The results of applying glutathione appear to be especially promising at this time, as it appears that a major disruption in the bond structure has taken place after approximately 72 hours. This result has been a primary target of research through this past year, and it may represent an important potential inhibitor to the structure growth. Listen to a Research Discussion on This Topic Additional Discussion:

Aurasma: Augmented Reality for Your Classroom After weeks of comparing reviews and conducting trials in my classroom, I can say unreservedly that Aurasma offers the best augmented reality (AR) experience for classrooms of any iOS or Android app. The Aurasma app is more versatile and classroom-friendly than any AR app; it enables teachers to bring curriculum to life, turning almost any environment into a classroom or object into a lesson. Read on to find out why no app does augmented reality like Aurasma. Methodology I began my tests by downloading three augmented reality apps — Layar, Anatomy 4D, and Aurasma v. 3.4.0 — on my iPhone 6 and iPad. I also borrowed my husband’s Samsung Galaxy S5 for a few days to test the apps on an Android phone. Scores User-Friendliness (4/5) A helpful tutorial pops up immediately, providing prompts to walk you through what you need to know. Teaching (4/5) The pedagogical potential of Aurasma is limitless, as it allows students to add dimension to material through video, animations, and so on. Background

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