Vitamin C - What You Don't Know May Kill You AND Why The USDA Is Wrong. Treatment of Distal Radius Fractures. Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo-/Radiotherapy and Aftercare: Results of a Retrospective, Multicentre, Epidemiological Cohort Study in Germany. + Author Affiliations Correspondence to: Professor Dr. med Josef Beuth, Institute for Naturopathy, University of Cologne, Joseph-Stelzmann-Str. 9/Building 35a, D-50931 Cologne, Germany.
Tel: +49 2214786414, Fax.: +49 2214787017, e-mail: hans.beuth@uk-koeln.de and Claudia Vollbracht, Pascoe pharmazeutische Präparate GmbH, D-35383 Giessen, Germany. Tel: +49 64179600, Fax: +49 6417960123, e-mail: claudia.vollbracht@pascoe.de Aim: The aim of the study was to evaluate under praxis conditions the safety and efficacy of intravenous (i.v.) vitamin C administration in the first postoperative year of women with breast cancer. Patients and Methods: Epidemiological multicentre cohort study, including 15 gynaecologists and general practitioners representatively distributed in Germany.
Received June 21, 2011. Effect of vitamin C on fracture healing in elderly Osteogenic Disorder Shionogi rats. High-dose vitamin C supplementation accelerates the Achilles tendon healing in healthy rats. Introduction This experimental study was performed to assess, whether or not, vitamin C, required during the collagen synthesis, would influence the Achilles tendon healing in a healthy rat model.
Materials and methods The right Achilles tendons of 42 healthy female Wistar Albino rats were completely ruptured. The rats were randomly divided into the vitamin C and control groups and both groups included third, tenth and twenty-first day subgroups. One hundred and fifty milligrams (1.5 cc) of vitamin C and 1.5 cc % 0.9 NaCl were injected once for every 2 days for the vitamin C and control groups, respectively.
Results Angiogenesis was more evident on the third day in the vitamin C group. Conclusion High-dose vitamin C supplementation once for every 2 days has stimulating effects on the Achilles tendon healing because of early angiogenesis and increased collagen synthesis in a healthy rat model. Antioxidant Micronutrients in Major Trauma and Burns: Evidence and Practice. Mette M.
Berger, MD, PhD Correspondence: Mette M Berger, MD, PhD, Department of Intensive Care Medicine and Burns Center, CHUV-BH08.660, CH-1011 Lausanne, Switzerland. Electronic mail may be sent to Mette.Berger@chuv.ch. There has been a growing interest in micronutrients as a result of their essential role in endogenous antioxidant defense mechanisms and immunity. Critically ill burn and trauma patients are characterized by an increased free radical production, which is proportional to the severity of the injury. Antioxidant therapy in intensive care : Current Opinion in Critical Care. Purpose of review: This review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies.
Recent findings: Several lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies improves the outcome of critically ill patients. Few data on the effects of N-acetylcysteine or trace elements have been published during the last two years.
Summary: Patients at risk of organ failure could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine. Vitamin C supplementation in pregnancy - The Cochrane Library - Rumbold. Background Vitamin C supplementation may help reduce the risk of pregnancy complications like pre-eclampsia, intrauterine growth restriction and maternal anaemia.
There is a need to evaluate the efficacy and safety of vitamin C supplementation in pregnancy. Objectives To evaluate the effects of vitamin C supplementation, alone or in combination with other separate supplements on pregnancy outcomes, adverse events, side-effects and use of health resources. Search methods We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (23 June 2004), Cochrane Central Register of Controlled Trials (The Cochrane Library 2004, Issue 2), MEDLINE (1966 to May 2004), Current Contents (1998 to May 2004) and EMBASE (1980 to May 2004).
Selection criteria All randomised or quasi-randomised controlled trials evaluating vitamin C supplementation in pregnant women. Vitamin C and human wound healing. Clinical studies provide evidence that wound healing in subjects judged not deficient in vitamin C can be significantly accelerated with supplements of this nutrient above the recommended daily allowance (RDA).
The authors administered daily dosages of 500 to 3,000 mg., which is roughly 8 to 50 times the RDA of 60 mg., to subjects recovering from surgery, other injuries, decubital ulcers, and leg ulcers induced by hemolytic anemia. Genetic impairment of collagen synthesis has also been observed to be responsive to ascorbic acid supplementation in an 8-year-old boy with Type VI Ehlers-Danlos syndrome. Four grams of ascorbic acid daily produced a significant improvement in the quality of newly synthesized collagen but did not alter that formed prior to the supplementation of C.
The combined evidence in this review provides a substantial base for further research, both clinical and experimental trials, concerning the interrelationships between vitamin C and the body's healing potential. The role of vitamin C in wound healing - Hunt - 2005 - British Journal of Surgery. A Randomized Trial of Replacement Antioxidant Vitamin Therap... : Journal of Trauma and Acute Care Surgery. High-dose vitamin C therapy for extensive deep dermal burns.
Plasma Vitamin C Levels Are Decreased and Correlated With Brain Damage in Patients With Intracranial Hemorrhage or Head Trauma. + Author Affiliations Correspondence to Maria Cristina Polidori, MD, Institute of Physiological Chemistry I, Heinrich-Heine University, D-40225 Düsseldorf, Germany.
E-mail polidori@uni-duesseldorf.de Abstract Background and Purpose—Free radical hyperproduction may play an important role in brain hemorrhage and ischemia/reperfusion injury. The aims of this study were to assess whether antioxidant depletion occurs after intracranial hemorrhage (ICH) and head trauma (HT) and to evaluate the relation between the diameter of the brain lesion, the degree of the neurological impairment, and any observed antioxidant changes.
Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma and subarachnoid hemorrhage patients. Linus Pauling Institute at Oregon State University. The anterior cruciate ligament (ACL) is an integral component of knee structure and function.
Its role is to limit excessive knee rotation and provide stability to the knee joint. Unfortunately, every year approximately 200,000 Americans injure their ACL. In nearly half the cases, this injury to the ligament requires reconstructive surgery. Immediate and persistent muscle dysfunction commonly follows the injury and surgical repair of a ruptured ACL. ptrehab.ucsf.edu/sites/ptrehab.ucsf.edu/files/documents/Vitamin%20C%20is%20Effective%20in%20Preventing%20Complex%20Regional%20Pain%20Syndrome%20in%20Adults%20Following%20Trauma_Pickering.pdf.