Gut Inflammation: 12 Causes (and 12 Effects) I’ve previously discussed how your gut microbiome influences essentially every aspect of your health.
However, gut inflammation is also a crucial determinant of intestinal and whole-body health. Read on to learn how various diet and lifestyle factors cause gut inflammation, the health consequences of a chronically inflamed gut, and practical strategies for alleviating inflammation and restoring gut health. Gut inflammation can contribute to the development of a wide range of serious conditions like type 2 diabetes, Parkinson’s disease, cardiovascular disease, and more.
Find out what causes inflammation and what you can do to correct it. #optimalhealth #chriskresser. Learning to control inflammation through the gut microbiota. In this Nature Medicine news article, Roxanne Khamsi reports on research around the world showing the microbiome exerts an influence on the human immune system.
If scientists knew how to control the key process of inflammation, they could profoundly influence the course of disorders such as inflammatory bowel disease, heart disease, and liver disease. Khamsi covers several possibilities on how gut microbiota could modulate inflammation, noting the challenges of establishing cause and effect. Probiotics and prebiotics are the two main products under investigation for altering microbial communities; of particular interest is how these two things might affect the production of gut microbe metabolites (such as fatty acids), which seem to be responsible for dampening inflammation in many situations. As for probiotics, Khamsi says there is a growing consensus that they work best if multiple strains of bacteria are delivered at once. Reference: Inflammatory Disease and the Human Microbiome - Amy D Proal - Discovery Medicine.
Abstract: The human body is a superorganism in which thousands of microbial genomes continually interact with the human genome.
A range of physical and neurological inflammatory diseases are now associated with shifts in microbiome composition. Seemingly disparate inflammatory conditions may arise from similar disruption of microbiome homeostasis. Intracellular pathogens long associated with inflammatory disease are able to slow the innate immune response by dysregulating activity of the VDR nuclear receptor. This facilitates the ability of other species to gradually accumulate in tissue and blood, where they generate proteins and metabolites that significantly interfere with the body’s metabolic processes. The microbes that contribute to this dysfunction are often inherited from family members. Introduction. Butyric Acid: an Ancient Controller of Metabolism, Inflammation and Stress Resistance?
An Interesting Finding Susceptible strains of rodents fed high-fat diets overeat, gain fat and become profoundly insulin resistant.
Dr. Jianping Ye's group recently published a paper showing that the harmful metabolic effects of a high-fat diet (lard and soybean oil) on mice can be prevented, and even reversed, using a short-chain saturated fatty acid called butyric acid (hereafter, butyrate). Health Diagrams III — Inflammation from Cell to Tissue. Functional profiling of the gut microbiome in disease-associated inflammation. The roles of the gut microbiota in inflammatory conditions have begun to be unraveled by functional profiling, or the assessment of host and microbial biomolecular activity in tandem with microbial community structure.
Assessment using nucleotide sequencing is typically a two-step process. First, genes, proteins, or protein families in the community (and sometimes in the host) are quantified; second, individual gene families are merged into higher-level pathways, such as metabolic pathways and functional modules. The Interplay Between Fiber and the Intestinal Microbiome in the Inflammatory Response. Introduction The nutritional importance of fiber has been long recognized.
Fiber has been included in the Nutrition Facts label following the 1990 Nutrition Labeling and Education Act, which sets the daily value (DV)3 for fiber at 12 g/1000 kcal. The 1997 revision of the Dietary Reference Intakes (DRI) established the adequate intake of fiber at ∼14 g/1000 kcal (1). At ∼13 g/1000 kcal (50 g/kg diet), the calculated nutrient density of fiber in purified rodent diets, such as AIN-76 and AIN-93, is similar to the human recommendation (2, 3).
Unfortunately, the presence of these recommendations does not signify a complete understanding of fiber nutrition. Top 19 Antinutrients in Plant Based Foods That Can Cause Inflammation - Selfhacked. Data Mining The Microbiome Toward A Cure For Inflammatory Disease. Strange, parasitic microbiome bacteria may responsible for inflammatory diseases — The American Microbiome Institute. The Gut Microbiota in Immune-Mediated Inflammatory Diseases. Bile flow, bacteria, and chronic inflammation - Hack your gut. The ultimate guide to fasting for gut health - Hack your gut. In my last blog Bile, bacteria, and chronic inflammation, I went over the importance of bile in establishing and maintaining a healthy gut and improving chronic inflammation.
One of the primary ways bile and the enterohepatic circulation help decrease systemic inflammation is through the processing of endotoxin. If you didn’t get a chance to check it out, read it here. The dangerous molecule in your gut that causes chronic inflammation - Hack your gut. Your gut is home to thousands of different species of bacteria that number in the trillions.
Many of these microbes are your friends. They help you: Digest and absorb nutrientsOptimize your immune systemSynthesize nutrients you can’tRegulate your mood and behavior. On the other end are your enemies. They make you sick, anxious, cause you to pack on the pounds, and contribute to many of the chronic inflammatory conditions we experience. Type 2 diabetesCardiovascular diseaseAlzheimer’s diseaseAutoimmune conditions (Type 1 diabetes, multiple sclerosis , allergies, arthritis) The single common thread among these conditions is chronic low level inflammation. Why physical activity is necessary to beat chronic inflammation. - Hack your gut.
Do you have problems with low energy and feeling winded any time you get up off the couch?
Can you feel your heart beat through your chest any time you make the slightest attempt to do anything physically active? If you notice these things coupled with poor detoxification, easy bruising, and slow wound healing you may be experiencing the anemia of chronic disease. And if you’re waiting around in bed hoping for it to go away you’re going to be very disappointed. In my estimation, physical activity is a critical component of getting your health back. Physical activity is an underappreciated way to improve health. Trying to increase bile output? This is your first step...gallbladder or not - Hack your gut. When I first began writing this blog I decided I wanted to start a private group on Facebook to help direct some of my research efforts.
I wanted to interact with my readers in a way that would allow me to dig in to some of the things that mattered most to them. If you’ve read most of my work, you know that I think bile flow is a crucial piece of the puzzle in optimizing gut health in general and digestion in particular. Bile plays many roles in helping set the microbiome by regulating motility, preventing SIBO by causing the secretion of antimicrobial peptides, and promoting an environment that selects for commensal microorganisms over pathogenic ones.
One of the most frequent questions I received early on was what someone without a gallbladder should do to optimize their bile output. I didn’t have an answer then, but after doing a little digging I believe I may have that answer. But, the answer I came across isn’t specific to people with poor bile flow or a missing gallbladder. The Inflammatory Cortisol Ballet Part 1.
This is a post from the Gut Critters blog that ended November1 8, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko
The Inflammatory Cortisol Ballet Part 2.
This is a post from the Gut Critters blog that ended November 18, 2016. Ray Medina gave permission for his material to be copied as long as it was attributed to him and not used for commercial purposes. – kiraonysko
The Inflammatory Cortisol Ballet Part 3.